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CCTS Protocols
ACTIVE PROTOCOLS
| PI | TITLE | |
| Ambrose, Catherine G. PhD | Identification of causative bacteria in osteomyelitis using rapid and sensitive 16SrRNA detection | |
| Arnett, Frank MD | An immunogenetic database and storage bank for rheumatic and autoimmune diseases | |
| Bell, Tanvir K. MD | Evaluation of cardiovascular effects of smoking cessation in HIV infected patients | |
| Brod, Staley A. MD | Prevention of cognitive decline in Alzheimer's disease by ingested interferon alpha | |
| Brod, Staley A. MD | A Phase II/III, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Rituximab (Mab Thera® /Rituxan® ) in Adults with Primary Progressive Multiple Sclerosis. | |
| Brod, Staley A. MD | Controlled high risk AVONEX (Interferon Beta-1a) multiple sclerosis prevention study in ongoing neurological surveillance (CHAMPIONS) | |
| Brod, Staley A. MD | Evaluation of plasma cortisol conentration after subcutaneous (S.C.) and intramuscular (I.M.) administration of H.P. Acthar® gel in healthy volunteers | |
| Brod, Staley A. MD | At risk for MS (Twin Study) | |
| Brod, Staley A. MD | Peripheral and central protein biomarkers of brain MR activity in demyelinating disease | |
| Brown, Deborah L. MD | Use of whole blood and cell-rich coagulation assays for the detectio of non-overt DIC in sepsis | |
| Brown, Deborah L. MD | A phase II/III trial evaluating the safety, pharmacokinetic properties and efficacy of a plasma derived anti-thromin III concentrate with administration in surgery, pregnancy and thromboembolic or thrombic events | |
| Bull, Joan M.C. MD | A phase II clinical trial of a timing/schedule optimizing combined-modality regimen: Cisplatin+ metronomic low-dose interferon (IFN-a) followed by Gemcitabine HCl (gemzar) in combination with mild, fever-range whole body hyperthermia (FR-WBH) in patients with advanced inoperable pancreatic cancer | |
| Bull, Joan M.C. MD | Phase II trial of mild WBH combined with liposomal doxorubicin/5-FU in patients with advanced malignancy | |
| Bull, Joan M.C. MD | Phase I-II clinical trial of cisplatin (Platinol) followed by gemcitabine HCl (Gemzar) in combination with mild, fever-range whole body hyperthermia (LL-WBH) at 40 c in patients with advanced malignancies | |
| Busaidy, Kamal, MD | Osteonecrosis risk assessment longitudinal (ORAL) study: Feasibility assessment | |
| Cox Jr, Charles S. MD | Safety of autologous stem cell treatment for traumatic brain injury in children | |
| Crommett, John MD | Vasopressin levels in patients with cervical spine injury and neurologic deficit | |
| Escobar, Miguel MD | Rituximab for the treatment of inhibitors in congential hemophilia A- The RICH study | |
| Estrada-Y-Martin, Rosa M. MD | Correlation between salivary cortisol and total serum cortisol to free serum cortisol in MICU patients with septic shock | |
| Evans, Patricia, MD | Free parking for parents of extremely low birth weight infants: would there be important benefits to the baby? | |
| Ferrendelli, James, MD | A double-blind, placebo-controlled, parallel-group study of rufinamide given as adjunctive therapy in patients with refractory partial seizures | |
| Frazier, Lorraine, DSN | Multi-detector CT angiography (MDCTA) for previously undetected cardiac and non-cardiac pathology in asymptomatic high-risk individuals | |
| Frost, Jeffrey PhD | A retrospective analysis of NET1 genes in human breast cancer | |
| Fuentes, Francisco MD | Genetic Analysis for Arrhythmic Disorders | |
| Fuentes, Francisco MD | A multicenter, double-blind, randomized study to establish the clinical benefit and safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin monotherapy in high-risk subjects presetning with acute coronary syndrome (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE IT) | |
| Fuentes, Francisco MD | Future revascularization evaluation in patients with diabetes mellitus: optimal management of multivessel disease. FREEDOM trial | |
| Fujise, Kenichi, MD | Fortilin - a novel compound for predicting development of atherosclerosis | |
| Gagliardi, Michael, MD | A phase III, multicenter, placebo-controlled, randomized, double-blind study to evaluate the safety and efficacy of PAROCHYMAL (ex vivo cultured adult human mesanchymal stem cells) intravenous infusion for the induction of remission in subjects experiencing treatment-refractory moderate-to-severe Crohn's disease | |
| Gambello, Michael J. MD PhD | Genetic characterization of patients with autism | |
| Guo, Dongchuan PhD | Genomic polymorphisms and sporadic thoracic aortic aneurysms and dissections | |
| Gupta, Monesha, MD; Portman, Ronald MD | Assessment of cardiovascular structure and function in hypertensive and normotensive children and assessment of vascular function in hypertensive children | |
| Hanis, Craig, PhD | Family studies of type 2 diabetes and impact of selected genes on development of type 2 diabetes in adults and adoelscents in the Lower Rio Grande Valley | |
| Hoelscher, Deanna PhD | Training interventions and genetics of exercise response study-the TIGER study | |
| Hoots, Keith MD | The molecular and clinical biology of von Willebrand disease | |
| Hoots, Keith MD | Modifiers of clinical phenotype in patients with hemophilia | |
| Jiang, Zhi-Dong PhD Okhuysen | Study of single nucleotide polymorphism (SNP) presence or absence in genes including intestinal receptors for cytokines or enteric pathogens in patients who are susceptible or resistant to travelers' diarrhea | |
| Katancik, James, DDS | Monocyte tissue factor expression in diabetes mellitus | |
| Kennedy, Kathleen MD, MPH | Cross-over trial for medical treatment for GERD in preterm infants | |
| Kennedy, Kathleen MD, MPH | Management of hyponatremia in preterm infants on diuretics | |
| Kleinerman, Eugenie S. MD | Randomized phase II study of vincristine, doxorubicin, cyclophosphamide and desrazoxane (VACdxr) with or without ImmTher for newly diagnosed high risk Ewing's Sarcoma | |
| Lavis, Victor R. MD | Bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) | |
| Levine, Robert MD | Proteomics of brain-trauma-associated elevated intracranial pressure (ICP) | |
| Lindsey, J. William MD | Open label study to evaluate the safety of Copaxone, and to monitor the neurologic course of disease of multiple sclerosis patients treated with Copaxone (Teva) | |
| Lindsey, J. William MD | Multicenter, double-blind, randomized study comparing the combined use of interferon beta-1a (Avonex) and glatiramer acetate (Copaxone) to either agent alone in patients with relapsing-remitting multiple sclerosis (CombiRx-Phase III) | |
| Lindsey, J. William MD | Acorda Protocol MSF03: Double-blind, placebo-controlled, 21-week, paralletl group study to evaluate the safety and efficacy of oral fampridine-SR (10 mg BID) in subjects with mutliple sclerosis | |
| Lindsey, J. William MD | The immune response to Epstein-Barr virus in multiple sclerosis (Normal Volunteers) | |
| Lindsey, J. William MD | The cellular immune response against
Epstein-Barr virus in multiple sclerosis |
|
| Madjid, Mohammad MD | Effect of statins on periodontal inflammation: a retrospective study | |
| Mayes, Maureen D. MD, MPH | The scleroderma family registry and DNA repository | |
| Mayes, Maureen D. MD, MPH | Long Term Bosentan Label Extension Of The RAPIDS-2 Study In Systemic Sclerosis Patients With Ischemic Digital Ulcers | |
| Mayes, Maureen D. MD, MPH | A randomized prospective Phase II/III multi-center study of high-dose immunosuppressive therapy using total body irraditaiton, cyclophosphamide and ATG with hematopoietic progenitor cells, apheresis CD34 enriched, for autologous use versus pulse intravenous cyclophosphamide for the treatment of severe systemic sclerosis | |
| Mayes, Maureen D. MD, MPH | Sociodemographic, behavioral and immunogenetic determinants of outcome in systemic sclerosis (SSc) | |
| Mayes, Maureen D. MD, MPH | An observational, long term, follow-up study of eligible individuals declining to participate in the scleroderma cyclophosphamide or transplantation (SCOT) study (SCOT Decliners Registry) | |
| Mayes, Maureen D. MD, MPH | Phase III open label study of a topical gel formulation of nitroglycerin, MQX-503 in the treatment and prevention of Raynaud's phenomenon | |
| Mayes, Maureen D. MD, MPH | Pilot study to examine the use of imatinib (Gleevec) for the treatiment of active alveolitis in systemic sclerosis | |
| McPherson, David, MD | Flow mediated vasodilatation in sickle cell disease | |
| Milewicz, Dianna M MD, PhD | Ethnic differences in the genetic basis of intracranial aneurysms | |
| Milewicz, Dianna M. MD, PhD | Genetic basis of vascular disease/TexGen research project | |
| Milewicz, Dianna M. MD, PhD | Genetic basis of aortic aneurysms | |
| Milewicz, Dianna, MD, PhD | Genetic basis for vascular disease (HVM1 and HVM2) | |
| Moeller, Frederick G. MD | Serotonin, drug use, and MDMA induced deficits | |
| Murray, Nancy DrPH | HEADS UP to Teachers and Parents | |
| Murthy, Jayasimha, MD | Thermal imaging, a novel non-contact method to detect apnea/hypopnea during polysomnography | |
| Navarro, Fernando, MD | PILOT STUDY: The physiological basis for dietary protein intolerance in children with autism | |
| Nelson, Flavia, MD | A 24-month double-blind, randomized, multicenter, placebo-controlled, parallel-group study comparing efficacy and safety of fingolimod (FTY 720) 1.25 mg and 0.50 mg administered orally once daily versus placebo in patinets with relapsing-remitting multiple sclerosis | |
| Northrup, Hope MD | Molecular Genetics of Neural Tube Defects | |
| Okhuysen, Pablo C. MD | Pathogenicity of enteroaggregative E. coli in adult volunteers | |
| Okhuysen, Pablo C. MD | Infectivity of Cryptosporidium parvum for adult humans | |
| Okhuysen, Pablo C. MD | A randomized, open label, phase III, international study of subcutaneous recombinant interleukin-2 (Proleukin) in patients with HIV-1 infection and CD4+ cell counts > 300/mm3: evaluation of subcutaneous Proleukin in a randomized international trial (ESPRIT) | |
| Okhuysen, Pablo C. MD | A randomized, open-label, international study of subcutaneous recombinant interleukin-2 (rIL-2, Aldesleukin) with and without concomitant antirertoviral therapy in patients with HIV-1 infection and CD4+ cell counts ≥300/mm³: study of Aldesluekin with and without antiretroviral therpay (ESPIRIT 002: STALWART) | |
| Okhuysen, Pablo C. MD | Seroepidemiologic study of enterotoxigenic Escherichia coli (ETEC) in US travelers to Mexico | |
| Parikh, Nehal A., DO | Structural brain abnormalities on volumetric MRI as a predictor of long-term neurosensory impairments in extremely low birth weight infants | |
| Parikh, Nehal A., DO | A randomized trial of hydrocortisone in very preterm infants at high risk for neurologic and pulmonary impairments | |
| Parikh, Nehal A., DO | Evaluation of diffusion tensor magnetic resonance imaging (DTI) as a predictor of neurosensory impairments in extremely preterm infants | |
| Paul, Sudhir PhD | The generation of a comprehensive universal autoimmune antibody library | |
| Ramin, Susan R. MD | A randomized clinical trial of treatment of mild gestational diabetes mellitus | |
| Restrepo, Blanca PhD | Altered expression of immune repsonse genes in tuberculosis patients with diabetes | |
| Reveille, John D. MD | A multicenter, randomized, double-blind, placebo-controlled trial of Golimumab, a fully human anti-TNF-α monoclonla antibody, administered subcutaneously in subjects with active ankylosing spondylitis | |
| Reveille, John D. MD | A phase III, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of rituximab in subjects with ISN/RPS class III or IV lupus nephritis | |
| Reveille, John D. MD | Genetics of ankylosing spondylitis pathogenesis (Australian-Anglo-American Spondylitis Consortium) (TASC) | |
| Reveille, John D. MD | Defining the spectrum of spondyloarthritis in family members of patients with ankylosing spondylitis | |
| Reveille, John D. MD | Cognitive function in SLE (COGNITION) | |
| Rhoads, Marc, MD | Effect of lactobacillus reuteri on colic symptoms and excessive breath hydrogen in infants with colic | |
| Robinson, Emily K. MD | A randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I, II breast cancer | |
| Ruppe, Mary D MD | Study of the endocrine regulators of phosphate homeostatis | |
| Samuels, Joshua, MD, MPH (was Portman, Ronald MD) | Chronic kidney disease in children study (CKiD) | |
| Schiess, Mya MD | A randomized, double-blind, active (pramipexole 0.5 mg tid) and placebo-controlled, efficacy study of pramipexole given 0.5 mg and 0.75 mg bid over a 12-week treatment phase in early Parkinson's disease patients | |
| Sellin, Joseph, MD | Impact of race and ethnicity on inflammatory bowel disease (IBD) | |
| Sereno, Anne B. PhD | Visual attention: Interactions and dissociations between reflexive and voluntary processes & neural substrates of attention and orienting | |
| Slater, Jeremy, MD | An international, double-blind, parallel-group, placebo-controlled, randomized study: evaluation of the efficacy and safety of brivaracetam in subjects 16 to 70 years old with partial onset seizures | |
| Smalling, Richard MD PhD | PATCAR Pilot Trial- Prehospital administration of thrombolytic therapy with urgent culprit artery revascularization | |
| Smith, Judith A. PharmD | Evaluation of the bioavailability of castor oil when administered orally vs intramuscularly vs as a vehicle for 17-α-hydroxyprogesterone in pregnant women | |
| Swann, Alan MD | Norepinephrine and impulsivity | |
| Taegtmeyer, Heinrich MD, Dphil | Glucolipotoxicity and cardiac dysfunction in obesity | |
| Tan, Filemon K. MD, PhD | Genetic and protein studies of fibrillin-1 in scleroderma | |
| Thomas, Eric MD, MPH | Improving teamwork for neonatal resuscitation | |
| Van Horn, Gage, MD | Evaluation of the Effectiveness of Subthalamic Deep Brain Stimulation and Its Effect on Neuropsychological Function in the Treatment of Medically Intractable Parkinson’s Disease | |
| Van Horn, Gage, MD | Prospective randomized investigation to evaluate incidence of headache reduction in subjects with migraine and PFO using the amplatzer PFO occluder compared to medical management. PREMIUM Trial | |
| Xia, James J., MD, PhD | Computer-aided surgical simulation for craniofacial surgery |
